Senior Scientist (Hematology Oncology)

Introduction to role:

We are seeking a highly motivated Senior Scientist in hematology oncology with a track record of scientific excellence to join our team in Waltham, MA. As a Senior Scientist, you will be leading from the bench and a member of the in vivo team focused on delivering in vivo pharmacology datasets that will have a direct impact on the drug discovery pipeline. Are you ready to make a difference in the fight against cancer?

Accountabilities:

Use in vivo technical skills to support oncology drug discovery by:

Developing and working with various in vivo models of cancer including subcutaneous and disseminated cell line and patient-derived xenograft models

Developing, designing, and executing tolerability, PKPD, and efficacy studies to build comprehensive in vivo pharmacology data packages to support drug discovery programs

Profiling tissue samples to explore mechanisms of drug response using both traditional and novel approaches

Work collaboratively across project teams and disciplines to advance projects

Work with various software programs and databases to capture all study data

Independently provide data analysis and interpretation

Present in relevant meetings to project teams and stakeholders Proactively and clearly communicate within the in vivo team and the broader AZ organization

Stay up to date with relevant scientific and technical expertise in cancer biology and pharmacology by actively reading the literature

Essential Skills/Experience:

PhD with >2 years or MS with >5 years of research experience in biology, pharmacology, or related field

Hands-on experience developing and working with hematological oncology in vivo models including xenografts (subcutaneous and disseminated models)

Ability to develop and deliver clear presentations and effectively communicate key messages

Ability to work both independently and within multidisciplinary project teams

Strong organizational and time management skills 

Experience using molecular and cell biology techniques such as Western blot, RT-PCR, flow cytometry, and ELISA/MSD

Strong interpersonal skills, with evidence of delivery in a team-oriented, collaborative environment

Familiarity with software programs include GraphPad Prism, Microsoft Office suite, and in vivo data capture systems (e.g. Study Log or similar)

Desirable Skills/Experience:

Prior experience in biotech or pharma

Experience delivering all aspects of PKPD, efficacy, and tolerability studies in xenograft models

Expertise in multiple myeloma, lymphoma, and/or acute myeloid leukemia biology

Experience with flow cytometry, including ability to design panels, profile markers in tissue using MACSQuant and/or BD cytometers, and analyze data in FlowJo

Experience with humanized xenograft models

Experience using small animal imaging modalities (e.g. Xenogen, ultrasound)

Understanding of pharmacology concepts such as pharmacodynamics and pharmacokinetics

Experience in assay development for complex systems (ex. in vivo samples, 3D cultures, co-culture etc.)

Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity, passion, and determination we are paving the way to change the practice of medicine in Oncology. Ready to make a difference? Apply today!

Date Posted

09-May-2025

Closing Date

18-May-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.